The chemoresistant and immunoevasive characteristics of leukaemia stem cells (LSCs) impede the treatment efficacy for acute myeloid leukaemia (AML). We find that inhibiting the tyrosine phosphatase SHP-1 effectively alters the metabolic state of LSCs, making them more susceptible to chemotherapy and immune surveillance in AML.

中文翻译：

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SHP-1 对 AML 化疗耐药和免疫监视的代谢调节

白血病干细胞（LSC）的化疗耐药和免疫逃避特性阻碍了急性髓系白血病（AML）的治疗效果。我们发现抑制酪氨酸磷酸酶 SHP-1 可以有效改变 LSC 的代谢状态，使它们在 AML 中更容易受到化疗和免疫监视的影响。