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Mapping the dysfunctome provides an avenue for targeted brain circuit therapy
Nature Neuroscience ( IF 25.0 ) Pub Date : 2024-02-22 , DOI: 10.1038/s41593-024-01572-z


Brain connections modulated by 534 deep-brain-stimulation electrodes revealed a gradient of circuits involved in dystonia, Parkinson’s disease, Tourette’s syndrome and obsessive-compulsive disorder. Together, these circuits begin to describe the human ‘dysfunctome’, a library of dysfunctional circuits that lead to various brain disorders.

中文翻译:

绘制功能障碍图谱为靶向脑回路治疗提供了途径

由 534 个深部脑刺激电极调节的大脑连接揭示了与肌张力障碍、帕金森病、抽动秽语综合症和强迫症有关的回路梯度。这些回路一起开始描述人类的“功能障碍组”,这是一个导致各种大脑疾病的功能失调回路库。
更新日期:2024-02-23
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