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Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota
Nature Metabolism ( IF 20.8 ) Pub Date : 2024-02-26 , DOI: 10.1038/s42255-024-00988-y
Huating Li , Lei Zhang , Jun Li , Qian Wu , Lingling Qian , Junsheng He , Yueqiong Ni , Petia Kovatcheva-Datchary , Rui Yuan , Shuangbo Liu , Li Shen , Mingliang Zhang , Bin Sheng , Ping Li , Kang Kang , Liang Wu , Qichen Fang , Xiaoxue Long , Xiaolin Wang , Yanli Li , Yaorui Ye , Jianping Ye , Yuqian Bao , Yueliang Zhao , Guowang Xu , Xinyu Liu , Gianni Panagiotou , Aimin Xu , Weiping Jia

Emerging evidence suggests that modulation of gut microbiota by dietary fibre may offer solutions for metabolic disorders. In a randomized placebo-controlled crossover design trial (ChiCTR-TTRCC-13003333) in 37 participants with overweight or obesity, we test whether resistant starch (RS) as a dietary supplement influences obesity-related outcomes. Here, we show that RS supplementation for 8 weeks can help to achieve weight loss (mean −2.8 kg) and improve insulin resistance in individuals with excess body weight. The benefits of RS are associated with changes in gut microbiota composition. Supplementation with Bifidobacteriumadolescentis, a species that is markedly associated with the alleviation of obesity in the study participants, protects male mice from diet-induced obesity. Mechanistically, the RS-induced changes in the gut microbiota alter the bile acid profile, reduce inflammation by restoring the intestinal barrier and inhibit lipid absorption. We demonstrate that RS can facilitate weight loss at least partially through B.adolescentis and that the gut microbiota is essential for the action of RS.



中文翻译:

抗性淀粉摄入通过重塑肠道微生物群促进人类减肥

新的证据表明,膳食纤维调节肠道微生物群可能为代谢紊乱提供解决方案。在一项针对 37 名超重或肥胖参与者的随机安慰剂对照交叉设计试验 (ChiCTR-TTRCC-13003333) 中,我们测试了抗性淀粉 (RS) 作为膳食补充剂是否会影响肥胖相关的结果。在这里,我们表明补充 RS 8 周有助于实现体重减轻(平均 -2.8 公斤)并改善体重超重个体的胰岛素抵抗。RS 的好处与肠道微生物群组成的变化有关。补充青春双歧杆菌 (一种与减轻研究参与者肥胖显着相关的物种)可以保护雄性小鼠免受饮食引起的肥胖。从机制上讲,RS 诱导的肠道微生物群变化会改变胆汁酸分布,通过恢复肠道屏障来减少炎症并抑制脂质吸收。我们证明,RS 至少可以部分通过青春双歧杆菌促进体重减轻,并且肠道微生物群对于 RS 的作用至关重要。

更新日期:2024-02-26
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