Expansion of HLA-DR Positive Peripheral Helper T and Naive B cells in Anticitrullinated Protein Antibody-Positive Individuals At Risk for Rheumatoid Arthritis,Arthritis & Rheumatology

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Expansion of HLA-DR Positive Peripheral Helper T and Naive B cells in Anticitrullinated Protein Antibody-Positive Individuals At Risk for Rheumatoid Arthritis
Arthritis & Rheumatology ( IF 13.3 ) Pub Date : 2024-02-27 , DOI: 10.1002/art.42839
Hideto Takada _{1,

2} , M. Kristen Demoruelle ₂ , Kevin D. Deane ₂ , Shohei Nakamura ₁ , Yasuhiro Katsumata ₁ , Katsunori Ikari _{3,

4} , Jane H. Buckner ₅ , William H. Robinson ₆ , Jennifer A. Seifert ₂ , Marie L. Feser ₂ , LauraKay Moss ₂ , Jill M. Norris ₇ , Masayoshi Harigai ₁ , Elena W.Y. Hsieh _{8,

9} , V. Michael Holers ₂ , Yuko Okamoto ₁

Affiliation

Division of Rheumatology, Department of Internal Medicine Tokyo Women's Medical University School of Medicine Tokyo Japan
Division of Rheumatology University of Colorado Anschutz Medical Campus Aurora CO USA
Department of Orthopedic Surgery Tokyo Women's Medical University School of Medicine Tokyo Japan
Division of Multidisciplinary Management of Rheumatic Diseases Tokyo Women's Medical University School of Medicine Tokyo Japan
Benaroya Research Institute Seattle WA USA
Division of Immunology and Rheumatology Stanford University Stanford CA USA
Department of Epidemiology, Colorado School of Public Health University of Colorado Anschutz Medical Campus Aurora CO USA
University of Colorado School of Medicine, Department of Immunology and Microbiology Aurora CO USA
University of Colorado School of Medicine, Children's Hospital Colorado, Department of Pediatrics Section of Allergy & Immunology Aurora CO USA

To investigate immune dysregulation in the peripheral blood that contributes to the pre-rheumatoid arthritis (RA) stage of RA development in anticitrullinated protein antibody (ACPA)+ individuals.

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