Binding of autoantibodies to autoantigens expressed on podocytes causes membranous nephropathy. New findings suggest that chimeric autoantibody receptor (CAAR) natural killer (NK) cells could be used to eliminate pathogenic autoantibody-producing cells in this disease.

The researchers conclude that CAAR NK and T cells can eliminate antibody-secreting target cells in an antigen-specific manner, demonstrating the feasibility of this strategy as a therapeutic approach. They suggest that use of their CAAR NK cell strategy might enable an off-the-shelf treatment with high specificity, low adverse effects and reduced long-term complications, patient burden and treatment costs compared to use of a more conventional autologous chimeric antigen receptor T cell approach.

自身抗体与足细胞上表达的自身抗原结合会导致膜性肾病。新的研究结果表明，嵌合自身抗体受体（CAAR）自然杀伤（NK）细胞可用于消除这种疾病中产生致病性自身抗体的细胞。

研究人员得出结论，CAAR NK 和 T 细胞可以以抗原特异性方式消除抗体分泌靶细胞，证明了该策略作为治疗方法的可行性。他们认为，与使用更传统的自体嵌合抗原受体 T 相比，使用他们的 CAAR NK 细胞策略可能会实现一种现成的治疗，具有高特异性、低不良反应，并减少长期并发症、患者负担和治疗成本。细胞方法。