Understanding the burden of pancreatic cystic lesions (PCLs) in the general population is important for clinicians and policymakers. In this systematic review, we sought to estimate the global prevalence of PCLs using magnetic resonance imaging (MRI) and to investigate factors that contribute to its variation. We searched MEDLINE, EMBASE, and Cochrane Central, from database inception through February 2023. We included full-text articles that reported the prevalence of PCLs using MRI in the general population. A proportional meta-analysis was performed, and the prevalence of PCLs was pooled using a random-effects model. Fifteen studies with 65,607 subjects were identified. The pooled prevalence of PCLs was 16% (95% confidence interval [CI], 13%–18%; I = 99%), most of which were under 10 mm. Age-specific prevalence of PCLs increased from 9% (95% CI, 7%–12%) at 50 to 59 years, to 18% (95% CI, 14%–22%) at 60 to 69 years, 26% (95% CI, 20%–33%) at 70 to 79 years, and 38% at 80 years and above (95% CI, 25%–52%). There was no difference in prevalence between sexes. Subgroup analysis showed higher PCL prevalence when imaging findings were confirmed by independent radiologist(s) (25%; 95% CI, 16%–33%) than when chart review alone was used (5%; 95% CI, 4%–7%; < .01). There was no independent association of PCL prevalence with geographic location (Europe, North America, or Asia), MRI indication (screening vs evaluation of non-pancreatic pathology), enrollment period, sample size, magnet strength (1.5 vs 3 tesla), and MRI sequence (magnetic resonance cholangiopancreatography vs no magnetic resonance cholangiopancreatography). In this systematic review, the global prevalence of PCLs using a highly sensitive noninvasive imaging modality ranged between 13% and 18%.

中文翻译：

---

全球普通人群胰腺囊性病变的磁共振成像患病率：系统评价和荟萃分析

了解普通人群中胰腺囊性病变 (PCL) 的负担对于临床医生和政策制定者来说非常重要。在这篇系统综述中，我们试图利用磁共振成像 (MRI) 来估计 PCL 的全球患病率，并调查导致其变化的因素。我们检索了 MEDLINE、EMBASE 和 Cochrane Central，从数据库建立到 2023 年 2 月。我们纳入了使用 MRI 报告普通人群中 PCL 患病率的全文文章。进行了比例荟萃分析，并使用随机效应模型汇总了 PCL 的患病率。共确定了 15 项涉及 65,607 名受试者的研究。 PCL 的汇总患病率为 16%（95% 置信区间 [CI]，13%–18%；I = 99%），其中大多数小于 10 mm。 PCL 的年龄特异性患病率从 50 至 59 岁的 9%（95% CI，7%–12%）增加到 60 至 69 岁的 18%（95% CI，14%–22%），26%（ 70 至 79 岁为 95% CI，20%–33%），80 岁及以上为 38%（95% CI，25%–52%）。性别之间的患病率没有差异。亚组分析显示，当影像学检查结果得到独立放射科医生证实时（25%；95% CI，16%–33%），PCL 患病率高于单独使用图表审查时的患病率（5%；95% CI，4%–7） %；< .01)。 PCL 患病率与地理位置（欧洲、北美或亚洲）、MRI 适应症（非胰腺病理的筛查与评估）、入组期、样本量、磁铁强度（1.5 与 3 特斯拉）和MRI 序列（磁共振胰胆管造影与无磁共振胰胆管造影）。在本次系统评价中，使用高灵敏度非侵入性成像方式的 PCL 的全球患病率在 13% 至 18% 之间。