AimTo assess the relationship between periodontitis and experimental pain tolerance.Materials and MethodsParticipants from the population‐based seventh survey of the Tromsø Study with data on periodontitis were included (n = 3666, 40–84 years old, 51.6% women). Pain tolerance was assessed through (i) pressure pain tolerance (PPT) test with a computerized cuff pressure algometry on the leg, and (ii) cold‐pressor tolerance (CPT) test where one hand was placed in circulating 3°C water. Cox proportional hazard regression was used to assess the association between periodontitis and pain tolerance adjusted for age, sex, education, smoking and obesity.ResultsIn the fully adjusted model using the 2012 Centers for Disease Control/American Academy of Periodntology case definitions for surveillance of periodontitis, moderate (hazard ratio [HR] = 1.09; 95% confidence interval [CI]: 1.01, 1.18) and severe (HR = 1.25, 95% CI: 1.11, 1.42) periodontitis were associated with decreased PPT. Using the 2018 classification of periodontitis, having Stage II/III/IV periodontitis was significantly associated with decreased PPT (HR = 1.09; 95% CI: 1.01, 1.18) compared with having no or stage I periodontitis. There were no significant associations between periodontitis and CPT in fully adjusted models.ConclusionsModerate and severe periodontitis was associated with experimental PPT.

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牙周炎与实验性压痛耐受性降低相关：2015-2016 年特罗姆瑟研究

目的评估牙周炎与实验性疼痛耐受性之间的关系。材料和方法特罗姆瑟研究第七次人口调查的参与者包含牙周炎数据（n= 3666，40-84 岁，51.6% 女性）。通过以下方式评估疼痛耐受性：(i) 使用计算机袖带压力计测腿部的压力疼痛耐受性 (PPT) 测试，以及 (ii) 冷加压耐受性 (CPT) 测试，其中将一只手放入 3°C 的循环水中。Cox 比例风险回归用于评估牙周炎与疼痛耐受性之间的关联，并根据年龄、性别、教育程度、吸烟和肥胖进行调整。结果在使用 2012 年疾病控制中心/美国牙周病学会病例定义进行牙周炎监测的完全调整模型中中度（风险比 [HR] = 1.09；95% 置信区间 [CI]：1.01, 1.18）和重度（HR = 1.25，95% CI：1.11, 1.42）牙周炎与 PPT 降低相关。根据 2018 年牙周炎分类，与无牙周炎或 I 期牙周炎相比，II/III/IV 期牙周炎与 PPT 降低显着相关（HR = 1.09；95% CI：1.01，1.18）。在完全调整的模型中，牙周炎和 CPT 之间没有显着相关性。结论中度和重度牙周炎与实验性 PPT 相关。