Endocannabinoid signaling regulates energy homeostasis, and is tightly associated with nonalcoholic fatty liver disease (NAFLD). The study previously finds that supplementation of docosahexaenoic acid (DHA) has superior function to ameliorate NAFLD compared with eicosapentaenoic acid (EPA), however, the underlying mechanism remains elusive. The present study aims to investigate whether DHA intervention alleviates NAFLD via endocannabinoid system.

中文翻译：

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二十二碳六烯酸通过抑制内源性大麻素系统调节非酒精性脂肪肝

内源性大麻素信号传导调节能量稳态，并与非酒精性脂肪肝病 (NAFLD) 密切相关。此前的研究发现，与二十碳五烯酸（EPA）相比，补充二十二碳六烯酸（DHA）对于改善 NAFLD 具有更优异的功能，但其潜在机制仍不清楚。本研究旨在探讨 DHA 干预是否通过内源性大麻素系统缓解 NAFLD。