Background Optimal methods for deploying electronic patient-reported outcomes (ePROs) to manage symptoms in routine oncologic practice remain uncertain. The eSyM symptom management program asks chemotherapy and surgery patients to self-report 12 symptoms regularly. Feedback from nurses and patients led to changing the recall period from the past 7 days to the past 24 hours. Methods Using questionnaires submitted during the 16-weeks surrounding the recall period change, we assessed the likelihood of reporting a severe, or a moderate-severe, symptom across all 12 symptoms and separately for the 5 most prevalent symptoms. Interrupted time series analyses modeled the effects of the change using generalized linear mixed-effects models. Surgery and chemotherapy cohorts were analyzed separately. Study-wide effects were estimated using a meta-analysis method. Results In total, 1,692 patients from 6 institutions submitted 7,823 eSyM assessments during the 16-weeks surrounding the recall period change. Shortening the recall period was associated with lower odds of severe symptom reporting in the surgery cohort (OR 0.65; 95% CI 0.46 to 0.93; p = .02) and lower odds of moderate-severe symptom reporting in the chemotherapy cohort (OR 0.83, 95% CI 0.71 to 0.97; p = .02). Among the most prevalent symptoms, 24-hour recall was associated with lower rate of reporting post-operative constipation, but no differences in reporting rates for other symptoms. Conclusion A shorter recall period was associated with a reduction in the proportion of patients reporting moderate-severe symptoms. The optimal recall period may vary depending on whether ePROs are collected for active symptom management, as a clinical trial endpoint, or another purpose. (Clinicaltrails.gov (NCT03850912)

中文翻译：

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回忆期变化对报告严重症状的影响：实用多中心试验的分析

背景 在常规肿瘤学实践中部署电子患者报告结果 (ePRO) 来管理症状的最佳方法仍不确定。eSyM 症状管理计划要求化疗和手术患者定期自我报告 12 种症状。根据护士和患者的反馈，召回期限从过去 7 天改为过去 24 小时。方法 使用围绕回忆期变化的 16 周内提交的调查问卷，我们评估了报告所有 12 种症状中的严重或中度至严重症状的可能性，并分别针对 5 种最常见的症状进行了评估。中断时间序列分析使用广义线性混合效应模型对变化的影响进行建模。手术和化疗队列分别进行分析。使用荟萃分析方法估计了研究范围内的影响。结果 在召回期变更前后的 16 周内，来自 6 个机构的 1,692 名患者总共提交了 7,823 份 eSyM 评估。缩短回忆期与手术队列中报告严重症状的几率较低（OR 0.65；95% CI 0.46 至 0.93；p = .02）和化疗队列中报告中重度症状的几率较低相关（OR 0.83， 95% CI 0.71 至 0.97；p = .02)。在最常见的症状中，24 小时回忆与术后便秘的报告率较低相关，但其他症状的报告率没有差异。结论 较短的回忆期与报告中重度症状的患者比例减少相关。最佳回忆期可能会有所不同，具体取决于收集 ePRO 是为了主动症状管理、作为临床试验终点还是其他目的。（Clinicaltrails.gov (NCT03850912)