The innovation of chiral ligands has been crucial for the asymmetric synthesis of functional molecules, as demonstrated by several types of widely applied “privileged” ligands. In this context, chiral pyridine-derived ligands, by far some of the oldest and most widely utilized ligands in catalysis, have attracted considerable research interest in the past half-century. However, the development of broadly applicable chiral pyridine units (CPUs) has been plagued by several intertwining challenges, thus delaying advancements in many asymmetric reactions.

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新型吡啶衍生手性配体的设计及其在不对称催化中的应用

手性配体的创新对于功能分子的不对称合成至关重要，几种广泛应用的“特权”配体就证明了这一点。在这种情况下，手性吡啶衍生配体是迄今为止催化中最古老和最广泛使用的配体，在过去的半个世纪中引起了相当大的研究兴趣。然而，广泛适用的手性吡啶单元（CPU）的开发一直受到一些相互交织的挑战的困扰，从而延迟了许多不对称反应的进展。