Extract

The enzyme leukotriene A₄ hydrolase (LTA4H) is classically known for its epoxide hydrolase activity that converts leukotriene A₄ (LTA₄) to the neutrophil chemoattractant LTB₄ [1]. In 2010, our group published a study in Science that demonstrated that during an influenza model of acute airway inflammation, LTA4H was released from cells to degrade proline-glycine-proline (PGP), a non-canonical CXCR1 and -2 agonist of polymorphonuclear neutrophil (PMN) recruitment and activation [2], thereby attenuating PMN inflammation [3].

中文翻译：

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囊性纤维化中中性粒细胞弹性蛋白酶依赖性 LTA4H 裂解改变其氨肽酶活性

提炼

_{白三烯 A 4}水解酶(LTA4H) 因其环氧化物水解酶活性而闻名，可将白三烯 A ₄ (LTA ₄ ) 转化为中性粒细胞趋化剂 LTB ₄ [1]。2010年，我们小组在《科学》杂志上发表了一项研究，证明在急性气道炎症的流感模型中，LTA4H从细胞中释放出来，降解脯氨酸-甘氨酸-脯氨酸（PGP），这是多形核中性粒细胞的非典型CXCR1和-2激动剂(PMN) 募集和激活 [2]，从而减轻 PMN 炎症 [3]。