Extract

Cystic fibrosis (CF) is one of the most common autosomal recessive genetic conditions that causes progressive lung disease and premature death [1]. Median survival worldwide is estimated to be around 50 years, but there is variation between countries [2–4]. Reasons for this variation are complex, and include genetic factors such as cystic fibrosis transmembrane conductance regulator (CFTR) genetic mutations in the population [5], as well as non-genetic factors such as access to lung transplantation and socioeconomic status (SES) [4].

中文翻译：

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欧洲囊性纤维化结果的社会经济差异：是时候缩小差距了

提炼

囊性纤维化（CF）是最常见的常染色体隐性遗传病之一，可导致进行性肺病和过早死亡[1]。全球中位生存期估计约为 50 年，但各国之间存在差异 [2-4]。这种变异的原因很复杂，包括遗传因素，例如人群中囊性纤维化跨膜电导调节因子（CFTR）基因突变[5]，以及非遗传因素，例如获得肺移植和社会经济地位（SES）[ 4]。