Inducing senescence in tumor cells can stimulate anti-tumor immune responses. In this issue of Cancer Cell, Colucci et al. demonstrate that the combination of the RAR agonist Adapalene with the chemotherapy drug Docetaxel enhances tumor-suppressing senescence and activates an anti-tumor immune response through natural killer cells.

中文翻译：

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释放安全有效的促衰老抗肿瘤策略

诱导肿瘤细胞衰老可以刺激抗肿瘤免疫反应。在本期《癌细胞》中，Colucci 等人。证明 RAR 激动剂阿达帕林与化疗药物多西紫杉醇的组合可增强肿瘤抑制衰老并通过自然杀伤细胞激活抗肿瘤免疫反应。