Hydrogen-bonded porous frameworks (HPFs) are versatile porous crystalline frameworks with diverse applications. However, designing chiral assemblies or biocompatible materials poses significant challenges. Peptide-based hydrogen-bonded porous frameworks (P-HPFs) are an exciting alternative to conventional HPFs due to their intrinsic chirality, tunability, biocompatibility, and structural diversity. Flexible, ultra-short peptide-based P-HPFs (composed of 3 or fewer amino acids) exhibit adaptable porous topologies that can accommodate a variety of guest molecules and capture hazardous greenhouse gases. Longer, folded peptides present challenges and opportunities in designing P-HPFs. This review highlights recent developments in P-HPFs using ultra-short peptides, folded peptides, and foldamers, showcasing their utility for gas storage, chiral recognition, chiral separation, and medical applications. It also addresses design challenges and future directions in the field.

中文翻译：

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肽氢键有机框架

氢键多孔框架（HPF）是具有多种应用的多功能多孔晶体框架。然而，设计手性组件或生物相容性材料提出了重大挑战。基于肽的氢键多孔框架 (P-HPF) 因其固有的手性、可调性、生物相容性和结构多样性而成为传统 HPF 的令人兴奋的替代品。灵活的超短肽基 P-HPF（由 3 个或更少的氨基酸组成）具有适应性强的多孔拓扑结构，可以容纳各种客体分子并捕获有害的温室气体。更长的折叠肽给 P-HPF 的设计带来了挑战和机遇。本综述重点介绍了使用超短肽、折叠肽和折叠体的 P-HPF 的最新进展，展示了它们在气体存储、手性识别、手性分离和医疗应用方面的实用性。它还解决了该领域的设计挑战和未来方向。