To investigate the role of antiphospholipid antibodies (aPLs) in the disease severity and prognosis of SLE-related thrombocytopenia (SLE-TP). This multicenter prospective study was conducted based on data from the CSTAR registry. TP was defined as a platelet count<100 × 109/L. Demographic characteristics, platelet count, clinical manifestations, disease activity, and autoantibody profiles were collected at baseline. Relapse was defined as the loss of remission. Bone marrow aspirate reports were also collected. A total of 350 SLE-TP patients with complete follow-up data, 194 (55.4%) were aPLs positive. At baseline, SLE-TP patients with aPLs had lower baseline platelet counts (61.0 × 109/L vs. 76.5 × 109/L, P<0.001), and a higher proportion of moderate to severe cases (24.2% vs. 14.1% ; 18.0% vs. 8.3%, P<0.001). SLE-TP patients with aPLs also had lower platelet counts at their lowest point (37.0 × 109/L vs. 51.0 × 109/L, P = 0.002). In addition, thean increasing number of aPLs types was associated with a decrease in the baseline and minimum values of platelets ( P<0.001, P = 0.001). During follow-up, SLE-TP carrying aPLs had a higher relapse rate (58.2% vs. 44.2%, P = 0.009) and a lower complete response (CR) rate. As the types of aPLs increased, the relapse rate increased, and the CR rate decreased. Furthermore, there was no significant difference in the ratio of granulocytes to red blood cells (G/E), the total number of megakaryocyte and categories. SLE-TP patients with positive aPLs had more severe disease a lower remission rate but a higher relapse rate.

中文翻译：

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抗磷脂抗体作为系统性红斑狼疮相关血小板减少症疾病严重程度和不良预后的潜在预测因子：现实世界 CSTAR 队列研究的结果

探讨抗磷脂抗体 (aPL) 在 SLE 相关血小板减少症 (SLE-TP) 疾病严重程度和预后中的作用。这项多中心前瞻性研究是根据 CSTAR 注册数据进行的。TP定义为血小板计数<100×109/L。在基线时收集人口统计学特征、血小板计数、临床表现、疾病活动性和自身抗体谱。复发被定义为缓解丧失。还收集了骨髓抽吸报告。共有350名具有完整随访数据的SLE-TP患者，194名（55.4%）aPLs阳性。基线时，患有aPL的SLE-TP患者基线血小板计数较低（61.0×109/L vs. 76.5×109/L，P<0.001），中度至重度病例比例较高（24.2% vs. 14.1%； 18.0% vs. 8.3%，P<0.001）。患有 aPL 的 SLE-TP 患者的血小板计数在最低点也较低（37.0 × 109/L 对比 51.0 × 109/L，P = 0.002）。此外，aPLs 类型数量的增加与血小板基线值和最小值的降低相关（P<0.001，P = 0.001）。随访期间，携带aPL的SLE-TP复发率较高（58.2% vs. 44.2%，P=0.009），完全缓解（CR）率较低。随着aPL类型的增加，复发率增加，CR率下降。此外，粒细胞与红细胞的比值（G/E）、巨核细胞总数及类别均无显着差异。aPLs 阳性的 SLE-TP 患者病情更严重，缓解率更低，但复发率更高。