Amplified Type I Interferon Response in Sjögren's Disease via Ectopic Toll-Like Receptor 7 Expression in Salivary Gland Epithelial Cells Induced by Lysosome-Associated Membrane Protein 3,Arthritis & Rheumatology

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Amplified Type I Interferon Response in Sjögren's Disease via Ectopic Toll-Like Receptor 7 Expression in Salivary Gland Epithelial Cells Induced by Lysosome-Associated Membrane Protein 3
Arthritis & Rheumatology ( IF 13.3 ) Pub Date : 2024-03-12 , DOI: 10.1002/art.42844
Hiroyuki Nakamura _{1,

2} , Tsutomu Tanaka ₁ , Changyu Zheng ₁ , Sandra A. Afione ₁ , Tatsuya Atsumi ₃ , Masayuki Noguchi ₄ , Fabiola Reis Oliveira ₅ , Ana Carolina F. Motta ₆ , Fernando Chahud ₇ , Eduardo M. Rocha ₈ , Blake M. Warner ₉ , John A. Chiorini ₁

Affiliation

AAV Biology Section National Institute of Dental and Craniofacial Research, National Institutes of Health Bethesda MD USA
Department of Rheumatology and Clinical Immunology Sapporo Medical University School of Medicine Sapporo Japan
Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine Hokkaido University Sapporo Japan
Division of Cancer Biology, Institute for Genetic Medicine Hokkaido University Sapporo Japan
Department of Clinical Medicine, Ribeirão Preto Medical School University of São Paulo São Paulo Brazil
Department of Stomatology, Public Health and Forensic Dentistry, School of Dentistry of Ribeirão Preto University of São Paulo São Paulo Brazil
Department of Pathology and Forensic Medicine, Ribeirão Preto Medical School University of São Paulo São Paulo Brazil
Department of Ophthalmology, Otorhinolaryngology, Head and Neck Surgery, Ribeirão Preto Medical School University of São Paulo São Paulo Brazil
Salivary Disorder Unit National Institute of Dental and Craniofacial Research, National Institutes of Health Bethesda MD USA

Lysosome-associated membrane protein 3 (LAMP3) misexpression in salivary gland epithelial cells plays a causal role in the development of salivary gland dysfunction and autoimmunity associated with Sjögren's disease (SjD). This study aimed to clarify how epithelial LAMP3 misexpression is induced in SjD.

中文翻译：

通过溶酶体相关膜蛋白 3 诱导的唾液腺上皮细胞中异位 Toll 样受体 7 表达增强干燥病中的 I 型干扰素反应

唾液腺上皮细胞中溶酶体相关膜蛋白 3 (LAMP3) 的错误表达在唾液腺功能障碍和与干燥病 (SjD) 相关的自身免疫的发生中起着因果作用。本研究旨在阐明 SjD 中如何诱导上皮 LAMP3 错误表达。

更新日期：2024-03-12

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