Purpose To compare the effectiveness and efficiency of a glued (sutureless) technique for amniotic membrane transplantation (AMT) with a traditional sutured one in the setting of acute Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Methods This retrospective cohort study evaluated all patients diagnosed with SJS/TEN between 2008 and 2020 within our hospital network who received AMT in the acute phase according to our protocol and had at least one ophthalmic follow-up in the chronic phase. Primary outcomes included best-corrected visual acuity (BCVA) at the most recent visit, presence of a severe ocular complication (SOC) via predefined criteria, time to procedure and duration of procedure. Random effects model analysis was used to evaluate the impact of potential covariates on outcome measures. Results A total of 23 patients (45 eyes) were included: 14 patients (27 eyes) in the AMT suture group and 9 patients (18 eyes) in the AMT glue group. There was no difference between the two groups in BCVA at the most recent visit (p=0.5112) or development of a SOC (p=1.000). The glue method was shorter in duration than the suture method (p<0.001). Random effects model additionally indicated that there was no difference in BCVA at most recent follow-up between patients who had received glued versus sutured AMT (p=0.1460). Conclusions Our glued technique for AMT is as effective as our sutured technique in stabilising the ocular surface and mitigating chronic ocular complications in SJS/TEN. The glued technique is also shorter in duration and performed more expediently than the sutured technique. Data are available upon reasonable request.

中文翻译：

---

胶合（无缝线）羊膜移植治疗急性史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症的长期结果：一项比较研究

目的 比较在急性 Stevens-Johnson 综合征/中毒性表皮坏死松解症 (SJS/TEN) 情况下羊膜移植 (AMT) 胶合（无缝线）技术与传统缝合技术的有效性和效率。方法 这项回顾性队列研究评估了我们医院网络中 2008 年至 2020 年间诊断为 SJS/TEN 的所有患者，这些患者根据我们的方案在急性期接受了 AMT，并在慢性期进行了至少一次眼科随访。主要结果包括最近一次就诊时的最佳矫正视力（BCVA）、根据预定标准是否存在严重眼部并发症（SOC）、手术时间和手术持续时间。使用随机效应模型分析来评估潜在协变量对结果测量的影响。结果共纳入23例患者（45眼）：AMT缝合组14例（27眼），AMT胶组9例（18眼）。两组在最近一次就诊时的 BCVA（p=0.5112）或 SOC 的发展（p=1.000）没有差异。胶合法的持续时间比缝合法短（p<0.001）。随机效应模型还表明，在最近的随访中，接受胶粘 AMT 与缝合 AMT 的患者之间的 BCVA 没有差异 (p=0.1460)。结论 我们的 AMT 粘合技术在稳定 SJS/TEN 眼表和减轻慢性眼部并发症方面与我们的缝合技术一样有效。胶合技术也比缝合技术持续时间更短并且执行更方便。数据可根据合理要求提供。