Research waste occurs when randomised controlled trial (RCT) outcomes are heterogeneous or overlook domains that matter to patients (eg, relating to symptoms or functions). In this systematic review, we reviewed the outcome measures used in 450 RCTs of adult unipolar and bipolar depression registered between 2018 and 2022 and identified 388 different measures. 40% of the RCTs used the same measure (Hamilton Depression Rating Scale [HAMD]). Patients and clinicians matched each item within the 25 most frequently used measures with 80 previously identified domains of depression that matter to patients. Seven (9%) domains were not covered by the 25 most frequently used outcome measures (eg, mental pain and irritability). The HAMD covered a maximum of 47 (59%) of the 80 domains that matter to patients. An interim solution to facilitate evidence synthesis before a core outcome set is developed would be to use the most common measures and choose complementary scales to optimise domain coverage. For the French and Dutch translations of the abstract see Supplementary Materials section.

中文翻译：

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抑郁症试验中结果测量的异质性以及结果测量内容与患者的相关性：系统评价

当随机对照试验（RCT）结果不一致或忽视对患者重要的领域（例如与症状或功能相关）时，就会出现研究浪费。在这项系统评价中，我们回顾了 2018 年至 2022 年间注册的 450 项成人单相和双相抑郁症随机对照试验中使用的结果指标，并确定了 388 项不同的指标。40% 的随机对照试验使用相同的测量方法（汉密尔顿抑郁评定量表 [HAMD]）。患者和临床医生将 25 种最常用测量中的每一项与之前确定的对患者重要的 80 个抑郁症领域进行匹配。25 个最常用的结果指标未涵盖七个 (9%) 领域（例如，精神痛苦和烦躁）。HAMD 最多涵盖了对患者重要的 80 个领域中的 47 个领域 (59%)。在制定核心成果集之前促进证据合成的临时解决方案是使用最常见的措施并选择补充尺度来优化领域覆盖范围。有关摘要的法语和荷兰语翻译，请参阅补充材料部分。