Immunology was one of the first biological fields to embrace chemical approaches. The development of new chemical approaches and techniques has provided immunologists with an impressive arsenal of tools to address challenges once considered insurmountable. This review focuses on advances at the interface of chemistry and immunobiology over the past two decades that have not only opened new avenues in basic immunological research, but also revolutionized drug development for the treatment of cancer and autoimmune diseases. These include chemical approaches to understand and manipulate antigen presentation and the T cell priming process, to facilitate immune cell trafficking and regulate immune cell functions, and therapeutic applications of chemical approaches to disease control and treatment.

中文翻译：

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化学免疫学：工具开发和应用的最新进展

免疫学是最早采用化学方法的生物学领域之一。新化学方法和技术的发展为免疫学家提供了令人印象深刻的工具库，以应对曾经被认为无法克服的挑战。本综述重点关注过去二十年化学和免疫生物学交叉领域的进展，这些进展不仅为基础免疫学研究开辟了新途径，而且彻底改变了治疗癌症和自身免疫性疾病的药物开发。其中包括理解和操纵抗原呈递和 T 细胞启动过程的化学方法，以促进免疫细胞运输和调节免疫细胞功能，以及化学方法在疾病控制和治疗中的治疗应用。