Aging is characterized by an ongoing struggle between the buildup of damage caused by a combination of external and internal factors. Aging has different effects on phagocytes, including impaired efferocytosis. A deficiency in efferocytosis can cause chronic inflammation, aging, and several other clinical disorders. Our review underscores the possible feasibility and extensive scope of employing dual targets in various age-related diseases to reduce the occurrence and progression of age-related diseases, ultimately fostering healthy aging and increasing lifespan.

中文翻译：

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衰老过程中的胞吞过程：年龄相关疾病的支持证据、机制和治疗前景

衰老的特点是外部和内部因素共同造成的损害累积之间的持续斗争。衰老对吞噬细胞有不同的影响，包括胞吞作用受损。胞吞作用的缺陷会导致慢性炎症、衰老和其他一些临床疾病。我们的综述强调了在各种与年龄相关的疾病中采用双重目标以减少与年龄相关的疾病的发生和进展，最终促进健康老龄化和延长寿命的可能可行性和广泛范围。