The composition of the gut microbiota has emerged as a tumour-extrinsic factor that modulates response to immune-checkpoint inhibitors (ICIs), although the lack of consistency in microbiota signatures across studies has limited their value as reliable biomarkers. Herein, we discuss a recent study in which longitudinal microbiome profiling identified several taxa that are persistently enriched in patients with melanoma and a favourable response to ICIs.

中文翻译：

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识别接受 ICI 的黑色素瘤患者的动态微生物群特征：机遇与挑战

肠道微生物群的组成已成为调节免疫检查点抑制剂（ICIs）反应的肿瘤外在因素，尽管各研究中微生物群特征缺乏一致性限制了它们作为可靠生物标志物的价值。在此，我们讨论了最近的一项研究，其中纵向微生物组分析确定了黑色素瘤患者中持续富集的几个分类群，并且对 ICI 有良好的反应。