Alzheimer disease has a sex bias: women are twice as likely as men to be affected. Studies have linked elevated follicle-stimulating hormone (FSH) levels to worsened Alzheimer disease pathology and cognitive decline in mice. Exploring the interaction of FSH with APOE4 has uncovered new aspects of Alzheimer disease. The therapeutic potential of FSH and gonadotropin-releasing hormone have also been highlighted.

中文翻译：

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下丘脑-垂体-性腺轴和阿尔茨海默病性别差异之谜

阿尔茨海默病有性别偏见：女性患病的可能性是男性的两倍。研究表明，卵泡刺激素（FSH）水平升高与小鼠阿尔茨海默病病理恶化和认知能力下降有关。探索 FSH 与 APOE4 的相互作用揭示了阿尔茨海默病的新方面。 FSH 和促性腺激素释放激素的治疗​​潜力也得到了强调。