Post-intensive care syndrome describes the physical, cognitive and emotional symptoms which persist following critical illness. At present there is limited understanding of the pathological mechanisms contributing to the development of post-intensive care syndrome. The aim of this systematic review was to synthesise current evidence exploring the association between inflammation and features of post-intensive care syndrome in survivors of critical illness. Relevant databases were systematically searched for studies of human participants exposed to critical illness. We sought studies that reported results for biomarkers with an identified role in the pathophysiology of inflammation obtained at any time-point in the patient journey and an outcome measure of any feature of post-intensive care syndrome at any point following hospital discharge. We included 32 studies, with 23 in the primary analysis and nine in a brain injury subgroup analysis. In the primary analysis, 47 different biomarkers were sampled and 44 different outcome measures were employed. Of the biomarkers which were sampled in five or more studies, interleukin-8, C-reactive protein and interleukin-10 most frequently showed associations with post-intensive care syndrome outcomes in 71%, 62% and 60% of studies, respectively. There was variability in terms of which biomarkers were sampled, time-points of sampling and outcome measures reported. Overall, there was mixed evidence of a potential association between an inflammatory process and long-term patient outcomes following critical illness. Further high-quality research is required to develop a longitudinal inflammatory profile of survivors of critical illness over the recovery period and evaluate the association with outcomes.

中文翻译：

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炎症与重症监护后综合征之间的关联：系统评价


重症监护后综合症是指危重疾病后持续存在的身体、认知和情绪症状。目前，对重症监护后综合征发生的病理机制了解有限。本系统评价的目的是综合当前的证据，探索危重病幸存者炎症与重症监护后综合征特征之间的关联。系统地搜索了相关数据库，以查找患有危重疾病的人类参与者的研究。我们寻求报告在患者旅程中任何时间点获得的在炎症病理生理学中具有确定作用的生物标志物结果的研究，以及出院后任何时间点重症监护后综合征任何特征的结果测量。我们纳入了 32 项研究，其中 23 项为主要分析，9 项为脑损伤亚组分析。在初步分析中，对 47 种不同的生物标志物进行了采样，并采用了 44 种不同的结果指标。在五项或更多研究中采样的生物标志物中，白细胞介素 8、C 反应蛋白和白细胞介素 10 最常见，分别在 71%、62% 和 60% 的研究中显示与重症监护后综合征结局相关。采样的生物标志物、采样的时间点和报告的结果测量存在差异。总体而言，有多种证据表明炎症过程与危重病后患者的长期结果之间存在潜在关联。需要进一步的高质量研究来开发危重疾病幸存者在恢复期间的纵向炎症特征，并评估与结果的关联。