Aims To examine differences between the eyes in choriocapillaris perfusion and choroidal thickness in children with myopic anisometropia. Methods In this observational and prospective study, 46 children with myopic anisometropia were enrolled. Choriocapillaris perfusion parameters, including the percentage of flow voids, the total number of flow voids and the average flow void area were obtained by optical coherence tomography angiography (OCTA). The OCTA image was divided into a 1 mm-diameter central circle (C1) and a 2.5 mm-diameter annulus (without the inner central 1 mm circle, C1-2.5). Both C1 and C1-2.5 are centred on the foveola. The C1-2.5 was divided into nasal (N1-2.5), temporal (T1-2.5), inferior (I1-2.5) and superior (S1-2.5) areas. Differences in these parameters in different regions between eyes were analysed. Results There were no significant differences in the percentage of flow voids and the average flow void area between the fellow eyes. The total number of signal voids was significantly higher in the less myopic eyes in C1-2.5 (p=0.032), S1-2.5 (p=0.008) and N1-2.5 (p=0.019). Changes in spherical equivalent refraction and axial length were both correlated with the changes in the total number of flow voids in N1-2.5 (R=−0.431, p=0.03; R=−0.297, p=0.047). Conclusions The choroid in the macular region becomes thinner and the total number of flow voids in the nasal macular region decreased with the amplitude of myopia. This suggests that a decrease in total number of flow voids may indicate an early change in myopia. No data are available.

中文翻译：

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儿童近视屈光参差的脉络膜毛细血管血流特征

目的 检查近视屈光参差儿童眼睛脉络膜毛细血管灌注和脉络膜厚度的差异。方法 在这项观察性和前瞻性研究中，纳入了 46 名近视屈光参差儿童。通过光学相干断层扫描血管造影（OCTA）获得脉络膜毛细血管灌注参数，包括流动空隙百分比、流动空隙总数和平均流动空隙面积。 OCTA图像被分为1毫米直径的中心圆（C1）和2.5毫米直径的环面（没有内部中心1毫米圆，C1-2.5）。 C1 和 C1-2.5 均以中央凹为中心。 C1-2.5 分为鼻区 (N1-2.5)、颞区 (T1-2.5)、下区 (I1-2.5) 和上区 (S1-2.5)。分析了眼睛不同区域这些参数的差异。结果对侧眼之间的流动空隙百分比和平均流动空隙面积没有显着差异。 C1-2.5 (p=0.032)、S1-2.5 (p=0.008) 和 N1-2.5 (p=0.019) 中近视程度较低的眼睛的信号空洞总数显着更高。 N1-2.5 中球面等效折射和轴长的变化均与流动空隙总数的变化相关（R=-0.431，p=0.03；R=-0.297，p=0.047）。结论 随着近视程度的加深，黄斑区脉络膜变薄，鼻黄斑区血流空洞总数减少。这表明流动空洞总数的减少可能表明近视的早期变化。无可用数据。