Accumulating evidence over the past decades has revealed an intricate relationship between dysregulation of cellular metabolism and the progression of atherosclerotic cardiovascular disease. However, an integrated understanding of dysregulated cellular metabolism in atherosclerotic cardiovascular disease and its potential value as a therapeutic target is missing. In this Review, we (1) summarize recent advances concerning the role of metabolic dysregulation during atherosclerosis progression in lesional cells, including endothelial cells, vascular smooth muscle cells, macrophages and T cells; (2) explore the complexity of metabolic cross-talk between these lesional cells; (3) highlight emerging technologies that promise to illuminate unknown aspects of metabolism in atherosclerosis; and (4) suggest strategies for targeting these underexplored metabolic alterations to mitigate atherosclerosis progression and stabilize rupture-prone atheromas with a potential new generation of cardiovascular therapeutics.

过去几十年积累的证据揭示了细胞代谢失调与动脉粥样硬化性心血管疾病进展之间的复杂关系。然而，人们对动脉粥样硬化性心血管疾病中细胞代谢失调及其作为治疗靶点的潜在价值缺乏全面的了解。在本综述中，我们 (1) 总结了有关病变细胞（包括内皮细胞、血管平滑肌细胞、巨噬细胞和 T 细胞）在动脉粥样硬化进展过程中代谢失调的作用的最新进展； （2）探索这些病变细胞之间代谢串扰的复杂性； (3) 重点介绍有望阐明动脉粥样硬化代谢未知方面的新兴技术； (4) 提出针对这些尚未探索的代谢改变的策略，以通过潜在的新一代心血管治疗药物减轻动脉粥样硬化进展并稳定易于破裂的动脉粥样硬化斑块。