The epidemiology of diabetic kidney disease (DKD) differs by sex, with a greater risk of kidney failure in men. New data suggest that sex differences in kidney metabolism may contribute to these differing outcomes.

In adults with chronic kidney disease, increased plasma levels of TCA cycle metabolites positively associated with male sex, diabetes and all-cause mortality and negatively associated with estimated glomerular filtration rate (eGFR). Among adults with diabetes, women without DKD had higher pyruvate levels than men with or without DKD and these levels positively associated with eGFR and negatively associated with all-cause mortality.

糖尿病肾病 (DKD) 的流行病学因性别而异，男性肾衰竭的风险更大。新数据表明，肾脏代谢的性别差异可能导致这些不同的结果。

在患有慢性肾病的成年人中，血浆 TCA 循环代谢物水平升高与男性、糖尿病和全因死亡率呈正相关，与估计肾小球滤过率 (eGFR) 呈负相关。在成年糖尿病患者中，没有 DKD 的女性的丙酮酸水平高于患有或不患有 DKD 的男性，并且这些水平与 eGFR 呈正相关，与全因死亡率呈负相关。