Many piercing-sucking insects have developed resistance or cross-resistance to many insecticides targeting insect neural nicotinic acetylcholine receptor (nAChR). Here we are aiming to present the discovery of a novel mesoionic insecticide, fenmezoditiaz, by BASF through structure-based drug design (SBDD) approaches. It has recently been added to the Insecticide Resistance Action Committee mode of classification (IRAC 4E). It is being developed for plant protection against piercing-sucking pests, especially rice hopper complex.

中文翻译：

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新型介离子杀虫剂 fenmezoditiaz 的发现及生物学表征

许多刺吸式昆虫对许多针对昆虫神经烟碱乙酰胆碱受体（nAChR）的杀虫剂产生了抗药性或交叉抗药性。在此，我们旨在展示巴斯夫通过基于结构的药物设计 (SBDD) 方法发现的一种新型介离子杀虫剂 fenmezoditiaz。它最近已被添加到杀虫剂抗药性行动委员会分类模式（IRAC 4E）中。它正在开发用于植物保护，防止刺吸式害虫，特别是稻飞虱复合体。