The regulation of MFG-E8 on the mitophagy in diabetic sarcopenia via the HSPA1L-Parkin pathway and the effect of D-pinitol,Journal of Cachexia, Sarcopenia and Muscle

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The regulation of MFG-E8 on the mitophagy in diabetic sarcopenia via the HSPA1L-Parkin pathway and the effect of D-pinitol
Journal of Cachexia, Sarcopenia and Muscle ( IF 8.9 ) Pub Date : 2024-03-29 , DOI: 10.1002/jcsm.13459
Wenqian Zhao _{1,

2,

3} , Bin Zhao ₄ , Xinyue Meng _{1,

2,

3} , Baoying Li _{2,

5} , Yajuan Wang _{1,

2,

3} , Fei Yu _{1,

2,

3} , Chunli Fu _{1,

2,

3} , Xin Yu _{1,

2,

3} , Xiaoli Li ₆ , Chaochao Dai ₂ , Jie Wang ₂ , Haiqing Gao _{1,

2,

3} , Mei Cheng _{1,

2,

3}

Affiliation

Diabetic sarcopenia is a disease-related skeletal muscle disorder that causes progressive symptoms. The complete understanding of its pathogenesis is yet to be unravelled, which makes it difficult to develop effective therapeutic strategies. This study investigates how MFG-E8 affects mitophagy and the protective role of D-pinitol (DP) in diabetic sarcopenia.

中文翻译：

MFG-E8通过HSPA1L-Parkin通路对糖尿病肌少症线粒体自噬的调节及D-松醇的作用

糖尿病肌少症是一种与疾病相关的骨骼肌疾病，会导致进行性症状。对其发病机制的完整了解尚未阐明，这使得制定有效的治疗策略变得困难。本研究探讨 MFG-E8 如何影响线粒体自噬以及 D-松醇 (DP) 在糖尿病肌少症中的保护作用。

更新日期：2024-03-29

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