Rheumatoid arthritis (RA) is an autoimmune disease in which the joint lining or synovium becomes highly inflamed and majorly contributes to disease progression. Understanding pathogenic processes in RA synovium is critical for identifying therapeutic targets. We performed laser capture microscopy (LCM) followed by RNA sequencing (LCM-RNAseq) to study regional transcriptomes throughout RA synovium.

中文翻译：

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激光捕获显微镜 RNA 测序用于类风湿关节炎期间滑膜病理学的拓扑图绘制


类风湿性关节炎 (RA) 是一种自身免疫性疾病，其中关节内膜或滑膜高度发炎，是导致疾病进展的主要原因。了解 RA 滑膜的致病过程对于确定治疗靶点至关重要。我们进行了激光捕获显微镜 (LCM)，然后进行 RNA 测序 (LCM-RNAseq)，以研究整个 RA 滑膜的区域转录组。