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Glycolytic activity and in vitro effect of the pyruvate kinase activator AG-946 in red blood cells from low-risk myelodysplastic syndromes patients: A proof-of-concept study
American Journal of Hematology ( IF 12.8 ) Pub Date : 2024-04-02 , DOI: 10.1002/ajh.27300 Bruno Fattizzo 1, 2 , Cristina Vercellati 1 , Anna Marcello 1 , Parija Patel 3 , Megan Wind‐Rotolo 3 , Loredana Pettine 1 , Marcella Bonanomi 4, 5 , Daniela Gaglio 4, 5 , Marta Bortolotti 1, 2 , Claudia Leoni 1, 2 , Elisa Fermo 1 , Paola Bianchi 1 , Anna Zaninoni 1 , Francesco Passamonti 1, 2 , Wilma Barcellini 1
American Journal of Hematology ( IF 12.8 ) Pub Date : 2024-04-02 , DOI: 10.1002/ajh.27300 Bruno Fattizzo 1, 2 , Cristina Vercellati 1 , Anna Marcello 1 , Parija Patel 3 , Megan Wind‐Rotolo 3 , Loredana Pettine 1 , Marcella Bonanomi 4, 5 , Daniela Gaglio 4, 5 , Marta Bortolotti 1, 2 , Claudia Leoni 1, 2 , Elisa Fermo 1 , Paola Bianchi 1 , Anna Zaninoni 1 , Francesco Passamonti 1, 2 , Wilma Barcellini 1
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Glycolytic activity and in vitro effect of the pyruvate kinase activator AG-946 in red blood cells from low-risk myelodysplastic syndromes patients. Data showed decreased glycolytic activity in red blood cells of 2/3 of patients with lower-risk MDS. These results highlight a potential effect of the PK activator in this setting.
中文翻译：
丙酮酸激酶激活剂 AG-946 对低危骨髓增生异常综合征患者红细胞的糖酵解活性和体外作用：概念验证研究
丙酮酸激酶激活剂 AG-946 对低危骨髓增生异常综合征患者红细胞的糖酵解活性和体外作用。数据显示，2/3 低危 MDS 患者的红细胞糖酵解活性降低。这些结果凸显了 PK 激活剂在此设置中的潜在作用。
更新日期：2024-04-02
中文翻译：
丙酮酸激酶激活剂 AG-946 对低危骨髓增生异常综合征患者红细胞的糖酵解活性和体外作用：概念验证研究
丙酮酸激酶激活剂 AG-946 对低危骨髓增生异常综合征患者红细胞的糖酵解活性和体外作用。数据显示，2/3 低危 MDS 患者的红细胞糖酵解活性降低。这些结果凸显了 PK 激活剂在此设置中的潜在作用。
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