Subsets of CD21^−/low memory B cells (MBCs), including double-negative (DN, CD27⁻IgD⁻) and Tbet⁺CD11c⁺ cells, are expanded in chronic inflammatory diseases. In rheumatoid arthritis (RA), CD21^−/low MBCs correlate with joint destruction. However, whether this is due to the Tbet⁺CD11c⁺ subset, its function and pathogenic contribution to RA are unknown. This study aims to investigate the association between CD21^−/lowTbet⁺CD11c⁺ MBCs and joint destruction as well as other clinical parameters and to elucidate their functional properties in patients with untreated RA (uRA).

中文翻译：

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专业抗原呈递 Tbet+CD11c+ B 细胞与未经治疗的类风湿性关节炎骨破坏的相关性


CD21 ^−/low 记忆 B 细胞 (MBC) 子集，包括双阴性（DN、CD27 ⁻ IgD ⁻ ）和 Tbet ⁺ CD11c ⁺ 细胞在慢性炎症性疾病中扩增。在类风湿性关节炎 (RA) 中，CD21 ^−/low MBC 与关节破坏相关。然而，这是否是由于 Tbet ⁺ CD11c ⁺ 子集所致，其功能和对 RA 的致病作用尚不清楚。本研究旨在调查 CD21 ^−/low Tbet ⁺ CD11c ⁺ MBC 与关节破坏以及其他临床参数之间的关联，并阐明其在患者中的功能特性患有未经治疗的 RA (uRA)。