Summary: Cell surface proteins represent ideal therapeutic targets because of their accessibility to antibodies, T cell–directed therapies, and radiotherapies, but there are only 25 therapeutically relevant cell surface targets for which cancer therapies are approved in the United States or European Union. This commentary calls for intensified research into mapping the universe of cell surface proteins – the cell surfaceome – in order to accelerate cancer drug development.

中文翻译：

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阐明细胞表面组以加速癌症药物开发

摘要：细胞表面蛋白代表了理想的治疗靶点，因为它们易于获得抗体、T 细胞定向疗法和放射疗法，但只有 25 个治疗相关的细胞表面靶点在美国或欧盟获得批准。该评论呼吁加强研究绘制细胞表面蛋白的宇宙（细胞表面组），以加速癌症药物的开发。