Summary: We explore the phenomenon of somatic mutations, including those in cancer driver genes, that are present in healthy, normal-appearing tissues and their potential implications for cancer development. We also examine the landscape of these somatic mutations, discuss the role of clonal cell competition and external factors like inflammation in enhancing the fitness of mutant clones, and conclude by considering how understanding these mutations will aid in prevention and/or interception of cancer.

中文翻译：

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正常组织的体细胞突变：暴风雨前的平静

摘要：我们探讨了健康、外观正常组织中存在的体细胞突变现象，包括癌症驱动基因中的突变现象及其对癌症发展的潜在影响。我们还研究了这些体细胞突变的情况，讨论了克隆细胞竞争和炎症等外部因素在增强突变克隆适应性方面的作用，并通过考虑了解这些突变如何有助于预防和/或拦截癌症来得出结论。