Summary: Nutrients are essential for supporting tumor growth and immune cell function in the tumor microenvironment, but emerging evidence reveals a paradoxical competition and collaboration between the metabolic demands of proliferating cancer cells and immune cell activation. Dietary interventions and metabolic immunoengineering offer promise to selectively modulate cancer and immune cell metabolism by targeting metabolic sensing processes rather than pathways directly, moving beyond conventional ideas and heralding an exciting new era of immunometabolism discovery and translation.

中文翻译：

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肿瘤-宿主共代谢共同塑造癌症免疫

摘要：营养素对于支持肿瘤微环境中的肿瘤生长和免疫细胞功能至关重要，但新的证据表明，增殖的癌细胞的代谢需求与免疫细胞激活之间存在矛盾的竞争与协作。饮食干预和代谢免疫工程有望通过针对代谢传感过程而非直接途径来选择性调节癌症和免疫细胞代谢，超越传统观念，预示着免疫代谢发现和转化的令人兴奋的新时代。