Summary: Beyond lipid membrane compartments, cells including cancer cells utilize various membraneless compartments, often termed biomolecular condensates, to regulate or organize key cellular processes underlying physiologic or pathologic phenotypes. In this commentary, the emergence of biomolecular condensation in cancer biology is highlighted, with a focus on key unanswered questions and with implications for improving the understanding of cancer pathogenesis and developing innovative cancer management strategies.

中文翻译：

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癌症中的相分离生物分子缩合：新视野和下一个前沿

摘要：除了脂质膜区室之外，包括癌细胞在内的细胞利用各种无膜区室（通常称为生物分子凝聚物）来调节或组织生理或病理表型背后的关键细胞过程。在这篇评论中，强调了癌症生物学中生物分子凝聚的出现，重点关注尚未解答的关键问题，以及对提高对癌症发病机制的理解和制定创新的癌症管理策略的影响。