Fundamental questions remain about the key mechanisms that initiate Alzheimer's disease (AD) and the factors that promote its progression. Here we report the successful generation of the first genetically engineered marmosets that carry knock-in (KI) point mutations in the presenilin 1 (PSEN1) gene that can be studied from birth throughout lifespan.

中文翻译：

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PSEN1 突变狨猴中常染色体显性阿尔茨海默病的早期分子事件

关于引发阿尔茨海默氏病（AD）的关键机制以及促进其进展的因素仍然存在基本问题。在这里，我们报告了第一批基因工程狨猴的成功培育，这些狨猴在早老素 1 ( PSEN1 ) 基因中携带敲入 (KI) 点突变，可以从出生到整个生命周期进行研究。