Plasma oxysterols are associated with serum lipids and dementia risk in older women,Alzheimer's & Dementia

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Plasma oxysterols are associated with serum lipids and dementia risk in older women
Alzheimer's & Dementia ( IF 14.0 ) Pub Date : 2024-04-04 , DOI: 10.1002/alz.13811
Michelle M. Dunk _{1,

2} , Stephen R. Rapp _{3,

4} , Kathleen M. Hayden ₃ , Mark A. Espeland _{3,

5,

6} , Ramon Casanova ₅ , JoAnn E. Manson _{7,

8} , Aladdin H. Shadyab _{9,

10} , Robert Wild ₁₁ , Ira Driscoll _{1,

12}

Affiliation

Department of Psychology University of Wisconsin – Milwaukee Milwaukee Wisconsin USA
Aging Research Center Department of Neurobiology, Care Sciences and Society Karolinska Institutet Stockholm Sweden
Department of Social Sciences and Health Policy Division of Public Health Sciences Wake Forest University School of Medicine Winston‐Salem North Carolina USA
Department of Psychiatry and Behavioral Medicine Wake Forest University School of Medicine Winston‐Salem North Carolina USA
Department of Biostatistics and Data Science Wake Forest University School of Medicine Winston‐Salem North Carolina USA
Sticht Center for Healthy Aging and Alzheimer's Prevention Wake Forest University School of Medicine Winston‐Salem North Carolina USA
Department of Medicine Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts USA
Department of Epidemiology Harvard T.H. Chan School of Public Health Boston Massachusetts USA
Herbert Wertheim School of Public Health and Human Longevity Science University of California San Diego La Jolla California USA
Division of Geriatrics, Gerontology, and Palliative Care, Department of Medicine University of California San Diego La Jolla California USA
Departments of Obstetrics and Gynecology, Biostatistics and Epidemiology Oklahoma University Health Sciences Center Oklahoma City Oklahoma USA
Wisconsin Alzheimer's Disease Research Center University of Wisconsin‐Madison Madison Wisconsin USA

Apolipoprotein E4 (APOE4) carriers’ tendency toward hypercholesterolemia may contribute to Alzheimer's disease (AD) risk through oxysterols, which traverse the blood-brain barrier.

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