Glycative stress, characterized by the formation and accumulation of advanced glycation end products (AGEs) associated with protein glycation reactions, has been implicated in inducing a decline of muscle function. Although the inverse correlation between glycative stress and muscle mass and strength has been demonstrated, the underlying molecular mechanisms are not fully understood. This study aimed to elucidate how glycative stress affects the skeletal muscle, particularly the adaptive muscle response to hypertrophic stimuli and its molecular mechanism.

中文翻译：

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糖化应激抑制超负荷小鼠骨骼肌肥大并损害细胞膜完整性


糖化应激的特征是与蛋白质糖化反应相关的晚期糖基化终末产物 (AGE) 的形成和积累，与诱导肌肉功能下降有关。尽管糖化应激与肌肉质量和力量之间的负相关已被证明，但潜在的分子机制尚未完全了解。本研究旨在阐明糖化应激如何影响骨骼肌，特别是肌肉对肥大刺激的适应性反应及其分子机制。