Modifying Effects of Genetic Variations on the Association Between Dietary Isothiocyanate Exposure and Non-muscle Invasive Bladder Cancer Prognosis in the Be-Well Study,Molecular Nutrition & Food Research

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Modifying Effects of Genetic Variations on the Association Between Dietary Isothiocyanate Exposure and Non-muscle Invasive Bladder Cancer Prognosis in the Be-Well Study
Molecular Nutrition & Food Research ( IF 5.2 ) Pub Date : 2024-04-06 , DOI: 10.1002/mnfr.202400087
Zinian Wang ₁ , Marilyn L. Kwan ₂ , Reina Haque _{3,

4} , Prashant K. Singh ₅ , Maciej Goniewicz ₆ , Rachel Pratt ₁ , Valerie S. Lee ₂ , Janise M. Roh ₂ , Isaac J. Ergas ₂ , Kimberly L. Cannavale ₃ , Ronald K. Loo ₇ , David S. Aaronson ₈ , Charles P. Quesenberry ₂ , Yuesheng Zhang ₉ , Christine B. Ambrosone ₁ , Lawrence H. Kushi ₂ , Li Tang ₁

Affiliation

Dietary isothiocyanate (ITC) exposure from cruciferous vegetable (CV) intake may improve non-muscle invasive bladder cancer (NMIBC) prognosis. This study aims to investigate whether genetic variations in key ITC-metabolizing/functioning genes modify the associations between dietary ITC exposure and NMIBC prognosis outcomes.

中文翻译：

Be-Well 研究中遗传变异对膳食异硫氰酸盐暴露与非肌肉侵袭性膀胱癌预后之间关系的影响

从十字花科蔬菜 (CV) 摄入中摄入的膳食异硫氰酸盐 (ITC) 可能会改善非肌层浸润性膀胱癌 (NMIBC) 的预后。本研究旨在调查关键 ITC 代谢/功能基因的遗传变异是否会改变饮食中 ITC 暴露与 NMIBC 预后结果之间的关联。

更新日期：2024-04-06

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