Approximately one in three survivors of critical illness suffers from intensive-care-unit-acquired weakness, which increases mortality and impairs quality of life. By counteracting immobilization, a known risk factor, active mobilization may mitigate its negative effects on patients. In this single-center trial, the effect of robotic-assisted early mobilization in the intensive care unit (ICU) on patients’ outcomes was investigated. We enrolled 16 adults scheduled for lung transplantation to receive 20 min of robotic-assisted mobilization and verticalization twice daily during their first week in the ICU (intervention group: IG). A control group (CG) of 13 conventionally mobilized patients after lung transplantation was recruited retrospectively. Outcome measures included the duration of mechanical ventilation, length of ICU stay, muscle parameters evaluated by ultrasound, and quality of life after three months. During the first week in the ICU, the intervention group received a median of 6 (interquartile range 3–8) robotic-assisted sessions of early mobilization and verticalization. There were no statistically significant differences in the duration of mechanical ventilation (IG: median 126 vs. CG: 78 h), length of ICU stay, muscle parameters evaluated by ultrasound, and quality of life after three months between the IG and CG. In this study, robotic-assisted mobilization was successfully implemented in the ICU setting. No significant differences in patients’ outcomes were observed between conventional and robotic-assisted mobilization. However, randomized and larger studies are necessary to validate the adequacy of robotic mobilization in other cohorts. Trial registration: This single-center interventional trial was registered in clinicaltrials.gov as NCT05071248 on 27/08/2021.

中文翻译：

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机器人辅助早期活动与传统活动对重症监护病房患者的影响：前瞻性介入队列研究与回顾性对照组分析

大约三分之一的危重病幸存者患有重症监护病房获得性虚弱，这会增加死亡率并损害生活质量。通过抵消固定这一已知的危险因素，主动活动可以减轻其对患者的负面影响。在这项单中心试验中，研究了重症监护病房 (ICU) 中机器人辅助早期活动对患者预后的影响。我们招募了 16 名计划进行肺移植的成年人，在入住 ICU 的第一周内每天接受两次每次 20 分钟的机器人辅助活动和垂直化（干预组：IG）。回顾性招募 13 名肺移植后常规活动患者组成的对照组 (CG)。结果指标包括机械通气持续时间、ICU 住院时间、超声评估的肌肉参数以及三个月后的生活质量。在 ICU 的第一周，干预组接受了中位数为 6 次（四分位数间距 3-8）次机器人辅助的早期活动和垂直化课程。 IG 和 CG 之间的机械通气持续时间（IG：中位数 126 与 CG：78 小时）、ICU 住院时间、超声评估的肌肉参数以及三个月后的生活质量没有统计学上的显着差异。在这项研究中，机器人辅助动员在 ICU 环境中成功实施。传统和机器人辅助动员之间没有观察到患者结果存在显着差异。然而，需要进行随机和更大规模的研究来验证机器人动员在其他人群中的充分性。试验注册：这项单中心介入试验于2021年8月27日在clinicaltrials.gov上注册为NCT05071248。