It is generally recognized that tumor cells proliferate more rapidly than normal cells. Due to such an abnormally rapid proliferation rate, cancer cells constantly encounter the limits of insufficient oxygen and nutrient supplies. To satisfy their growth needs and resist adverse environmental events, tumor cells modify the metabolic pathways to produce both extra energies and substances required for rapid growth. Realizing the metabolic characters special for tumor cells will be helpful for eliminating them during therapy. Cell death is a hot topic of long-term study and targeting cell death is one of the most effective ways to repress tumor growth. Many studies have successfully demonstrated that metabolism is inextricably linked to cell death of cancer cells. Here we summarize the recently identified metabolic characters that specifically impact on different types of cell deaths and discuss their roles in tumorigenesis.

中文翻译：

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肿瘤发生中代谢与细胞死亡之间的串扰

人们普遍认为肿瘤细胞比正常细胞增殖更快。由于异常快速的增殖速度，癌细胞不断遇到氧气和营养供应不足的限制。为了满足生长需要并抵抗不利的环境事件，肿瘤细胞会改变代谢途径以产生快速生长所需的额外能量和物质。了解肿瘤细胞特有的代谢特征将有助于在治疗过程中消除肿瘤细胞。细胞死亡是长期研究的热点话题，靶向细胞死亡是抑制肿瘤生长的最有效方法之一。许多研究已成功证明新陈代谢与癌细胞的细胞死亡有着千丝万缕的联系。在这里，我们总结了最近发现的专门影响不同类型细胞死亡的代谢特征，并讨论了它们在肿瘤发生中的作用。