To evaluate the prognostic ability of non-contact esthesiometry corneal and lid margin sensitivity measurements in detecting symptoms and signs of dry eye disease, as defined by the global consensus TFOS DEWS II criteria. A total of 87 community residents (58 females; mean ± SD age, 53 ± 16 years) were recruited in an investigator-masked, prospective, prognostic accuracy study. Dry eye symptomology, tear film parameters, and ocular surface characteristics were evaluated in a single clinical session, and non-contact esthesiometry corneal and lid margin sensitivity measurements performed by an independent masked assessor. Overall, 49 (56%) participants fulfilled the TFOS DEWS II criteria for dry eye disease, while 57 (66%) exhibited clinical symptoms, and 67 (77%) had positive signs. The prognostic abilities of corneal and lid margin sensitivity measurements were significantly greater than chance for the detection dry eye signs (both p ≤ 0.03), but not for symptoms or overall disease diagnosis (all p > 0.10). The Youden-optimal prognostic cut-offs for corneal and lid margin sensitivity thresholds were both ≥0.8 mbar for the detection of clinical dry eye signs. Lid margin sensitivity demonstrated marginally higher predictive performance than corneal sensitivity (C-statistic, 0.688 versus 0.658), and was significantly correlated with tear film stability, corneal, conjunctival and lid wiper staining (all p < 0.05). Corneal and lid margin sensitivity demonstrated moderate prognostic utility for detecting clinical dry eye signs. Future research is warranted to investigate the utility of incorporating non-contact esthesiometry in the workup for dry eye disease and neurotrophic keratopathy.

中文翻译：

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干眼病的角膜和眼睑边缘敏感性的预测性能：一项研究者掩盖的前瞻性预后准确性研究

根据全球共识 TFOS DEWS II 标准的定义，评估非接触式审美角膜和眼睑边缘敏感性测量在检测干眼病症状和体征方面的预后能力。总共招募了 87 名社区居民（58 名女性；平均±SD 年龄，53±16 岁）参与一项研究者隐蔽的前瞻性预后准确性研究。在单次临床会议中评估干眼症状、泪膜参数和眼表特征，并由独立的蒙面评估员进行非接触式美学角膜和眼睑边缘敏感性测量。总体而言，49 名（56%）参与者符合 TFOS DEWS II 干眼病标准，57 名（66%）名参与者表现出临床症状，67 名（77%）名参与者出现阳性体征。角膜和眼睑边缘敏感性测量的预后能力显着高于检测干眼症状的机会（均 p ≤ 0.03），但对于症状或总体疾病诊断的机会则不然（均 p > 0.10）。用于检测临床干眼症状的角膜和眼睑边缘敏感性阈值的 Youden 最佳预后截止值均≥0.8 mbar。睑缘敏感性表现出比角膜敏感性稍高的预测性能（C 统计量，0.688 与 0.658），并且与泪膜稳定性、角膜、结膜和睑擦拭器染色显着相关（所有 p < 0.05）。角膜和眼睑边缘敏感性对于检测临床干眼症状具有中等的预后效用。未来的研究有必要调查非接触式美学测量在干眼病和神经营养性角膜病检查中的实用性。