Anterior urethral stricture disease (aUSD) is a complex, heterogeneous condition which is idiopathic in origin for most men. This gap in knowledge rarely affects the current management strategy for aUSD, as urethroplasty does not generally consider etiology. However, as we transition towards personalized, minimally invasive treatments for aUSD and begin to consider aUSD prevention strategies, disease pathophysiology will become increasingly important. The purpose of this study was to perform a deep phenotype of men undergoing anterior urethroplasty for aUSD. We hypothesized that unique biologic signatures and potential targets for intervention would emerge based on stricture presence/absence, stricture etiology, and the presence/absence of stricture inflammation.

中文翻译：

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前尿道狭窄的深层表型分析：表征炎症、纤维化、患者病史和疾病病理生理学之间的关系。

前尿道狭窄疾病 (aUSD) 是一种复杂的异质性疾病，对于大多数男性来说都是特发性的。这种知识差距很少影响 aUSD 目前的管理策略，因为尿道成形术通常不考虑病因。然而，随着我们向 aUSD 的个性化、微创治疗过渡并开始考虑 aUSD 预防策略，疾病病理生理学将变得越来越重要。本研究的目的是对接受前尿道成形术的男性进行深层表型分析。我们假设，根据狭窄的存在/不存在、狭窄病因以及狭窄炎症的存在/不存在，将出现独特的生物学特征和潜在的干预目标。