Organ morphogenesis begins with proliferation, which results in tissue pressures and site-specific YAP expression, nuclear translocation and signalling. A study now reports the involvement of anisotropy, localized pressure and YAP signalling in organizer-forming cascades, introducing a new chapter of molecular mechanobiology of organogenesis.

中文翻译：

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器官发生过程中的组织压力和 YAP

器官形态发生始于增殖，从而产生组织压力和位点特异性 YAP 表达、核易位和信号传导。现在的一项研究报告了各向异性、局部压力和 YAP 信号在组织者形成级联中的参与，为器官发生的分子力学生物学开辟了新的篇章。