We evaluated the in vitro effects of lyophilization for 2 vesicular stomatitis virus–based vaccines by using 3 stabilizing formulations and demonstrated protective immunity of lyophilized/reconstituted vaccine in guinea pigs. Lyophilization increased stability of the vaccines, but specific vesicular stomatitis virus–based vaccines will each require extensive analysis to optimize stabilizing formulations.

中文翻译：

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冻干水泡性口炎病毒疫苗在动物模型中的保护作用

我们使用 3 种稳定制剂评估了 2 种水疱性口炎病毒疫苗的冻干体外效果，并在豚鼠中证明了冻干/重构疫苗的保护性免疫力。冻干提高了疫苗的稳定性，但基于特定水泡性口炎病毒的疫苗都需要进行广泛的分析以优化稳定配方。