Summary: Rosano, Sofyali, Dhiman, and colleagues show that epigenetic-related changes occur in endocrine therapy (ET)-induced dormancy in estrogen receptor positive (ER+) breast cancer, as well as in its reawakening. Targeting these epigenetic changes blocks the entrance to dormancy and reduces the persister cancer cell population, enhancing the cytotoxic effects of ET in vitro. See related article by Rosano et al. (9).

中文翻译：

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内分泌治疗耐药中癌细胞休眠和唤醒的表观遗传控制

摘要：Rosano、Sofyali、Dhiman 及其同事表明，在雌激素受体阳性 (ER+) 乳腺癌的内分泌治疗 (ET) 诱导的休眠及其重新唤醒过程中，会发生与表观遗传相关的变化。针对这些表观遗传变化可阻止进入休眠状态并减少持续存在的癌细胞群，从而增强 ET 的体外细胞毒性作用。请参阅 Rosano 等人的相关文章。 （9）。