From signaling mediators in stem cells to markers of differentiation and lineage commitment to facilitators for the entry of viruses, such as HIV-1, cell surface heparan sulfate (HS) glycans with distinct modification patterns play important roles in hematopoietic biology. In this review, we provide an overview of the importance of HS and the proteoglycans (HSPGs) to which they are attached within the major cellular subtypes of the hematopoietic system. We summarize the roles of HSPGs, HS, and HS modifications within each main hematopoietic cell lineage of both myeloid and lymphoid arms. Lastly, we discuss the biological advances in the detection of HS modifications and their potential to further discriminate cell types within hematopoietic tissue.

中文翻译：

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硫酸乙酰肝素和硫酸乙酰肝素蛋白多糖在造血中的作用

从干细胞中的信号传导介质到分化和谱系定型标记，再到 HIV-1 等病毒进入的促进剂，具有不同修饰模式的细胞表面硫酸乙酰肝素 (HS) 聚糖在造血生物学中发挥着重要作用。在这篇综述中，我们概述了 HS 及其在造血系统主要细胞亚型中所附着的蛋白聚糖 (HSPG) 的重要性。我们总结了 HSPG、HS 和 HS 修饰在髓系和淋巴系各主要造血细胞谱系中的作用。最后，我们讨论了 HS 修饰检测的生物学进展及其进一步区分造血组织内细胞类型的潜力。