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Hostile bile limits anti-cancer immunity
Immunity ( IF 32.4 ) Pub Date : 2024-04-09 , DOI: 10.1016/j.immuni.2024.03.006
Pavitha Parathan , Lisa A. Mielke

Various microbial metabolites promote cell transformation. In this issue of Immunity, Cong et al. show that deoxycholic acid (DCA), a microbial metabolite of bile, promotes tumor growth by suppressing antitumor CD8+ T cell responses via dysregulation of calcium efflux.



中文翻译:

敌意胆汁限制抗癌免疫力

各种微生物代谢物促进细胞转化。在本期《免疫》中,Cong 等人。研究表明,脱氧胆酸(DCA)是胆汁的微生物代谢产物,通过钙流出失调抑制抗肿瘤 CD8 + T 细胞反应,从而促进肿瘤生长。

更新日期:2024-04-09
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