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Sensory neurons: An integrated component of innate immunity
Immunity ( IF 32.4 ) Pub Date : 2024-04-09 , DOI: 10.1016/j.immuni.2024.03.008
Liwen Deng , Jacob E. Gillis , Isaac M. Chiu , Daniel H. Kaplan

The sensory nervous system possesses the ability to integrate exogenous threats and endogenous signals to mediate downstream effector functions. Sensory neurons have been shown to activate or suppress host defense and immunity against pathogens, depending on the tissue and disease state. Through this lens, pro- and anti-inflammatory neuroimmune effector functions can be interpreted as evolutionary adaptations by host or pathogen. Here, we discuss recent and impactful examples of neuroimmune circuitry that regulate tissue homeostasis, autoinflammation, and host defense. Apparently paradoxical or conflicting reports in the literature also highlight the complexity of neuroimmune interactions that may depend on tissue- and microbe-specific cues. These findings expand our understanding of the nuanced mechanisms and the greater context of sensory neurons in innate immunity.

中文翻译:

感觉神经元:先天免疫的一个组成部分

感觉神经系统具有整合外源威胁和内源信号以介导下游效应功能的能力。感觉神经元已被证明可以激活或抑制宿主对病原体的防御和免疫力,具体取决于组织和疾病状态。通过这个镜头,促炎和抗炎神经免疫效应器功能可以解释为宿主或病原体的进化适应。在这里,我们讨论调节组织稳态、自身炎症和宿主防御的神经免疫回路的最新且有影响力的例子。文献中显然自相矛盾或相互矛盾的报告也强调了神经免疫相互作用的复杂性,这可能取决于组织和微生物特异性线索。这些发现扩展了我们对先天免疫中感觉神经元的微妙机制和更大背景的理解。
更新日期:2024-04-09
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