A new engineering strategy for improving the biosynthesis of secondary metabolites in Streptomyces has been developed through the analysis of genes co-evolved with biosynthetic gene clusters. This strategy has been verified in 11 Streptomyces strains to enhance production of 16,385 metabolites, showing potential applications in drug discovery and industrial production.

中文翻译：

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共同进化的基因改善了次生代谢物的生物合成

通过分析与生物合​​成基因簇共同进化的基因，开发了一种改善链霉菌次生代谢物生物合成的新工程策略。该策略已在 11 种链霉菌菌株中得到验证，可提高 16,385 种代谢物的产量，显示出在药物发现和工业生产中的潜在应用。